Scientific Career

PhD Kerstin Wagner

Education / Study
1987 Abitur [general qualification for university entrance]
at the Anger-Gymnasium in Jena
1987 - 1992

Study of chemistry
at the Friedrich Schiller University Jena (FSU)

- main subject 'Organic synthesis chemistry'
- mandatory elective courses 'Bioorganic chemistry' and 'Pharmaceutical synthesis'
June 1992 Diploma thesis
in organic / polymer chemistry at the Friedrich Schiller University Jena (FSU)

'Zur Synthese, Charakterisierung und Folgechemie von C-6-Carboxycellulose'
[Synthesis, characterization and following reactions of C-6 carboxy cellulose]

May 1997

PhD thesis
in organic / polymer chemistry at the Friedrich Schiller University Jena (FSU)

'Neue Funktionspolymere durch regioselektive Synthese und Folgechemie der p-Toluensulfonsäureester der Cellulose'
[New functionalized polymers by regioselective synthesis and following reactions of cellulose p-toluenesulfonates]

Main Research Topics / Projects
September 1992 -
April 1994

BMFT grant
 'Homogenderivatisierung von Cellulose' [Cellulose derivatization under homogeneous solution conditions]
FSU, Institute for Organic and Macromolecular Chemistry, Dept. 'Organische Naturstoffchemie', Prof. Dr. D. Klemm

Synthese carboxylgruppenhaltiger Cellulosederivate durch Oxidationsreaktionen [Synthesis of COOH-group containing cellulose derivatives by oxidation reactions]
April 1994 -
November 1994

Research stay
at the AKZO NOBEL Research Laboratories in Obernburg/Main
Dr. M. Diamantoglou

Homogene Veresterung von Cellulose [Homogenous esterification of cellulose]
  • Synthese und Charakterisierung von p-Toluensulfonsäureestern der Cellulose [Synthesis and characterization of p-toluenesulfonates of cellulose]
  • Entwicklung neuer Synthesestrategien zur Darstellung von neuartigen Funktionspolymeren mit interessanten Werkstoffeigenschaften [Development of new synthesis strategies to prepare novel functionalized polymers with interesting material characteristics
January 1995 -
April 1995		 Research practical course
'Darstellung von Siderophor-Antibiotika-Konjugaten' [Synthesis of siderophore-antibiotica conjugates]
 Hans-Knöll-Institut für Naturstoff-Forschung Jena (HKI), Dept. 'Naturstoffchemie', Prof. Dr. U. Gräfe
  • organisch-chemische Modifizierung von Siderophoren [Organic-chemical modification of siderophores]
May 1995 -
May 1997		 DFG project
'Chemische und enzymatische Synthese von Stärke- und Cellulosederivaten mit gesteuerter Substituentenverteilung' [Chemical and enzymatical synthesis of starch and cellulose derivatives with controlled substitution distribution]
 FSU, Institute for Organic and Macromolecular Chemistry, Dept. 'Organische Naturstoffchemie', Prof. Dr. D. Klemm / Dr. Th. Heinze

PhD thesis

Neue Funktionspolymere durch regioselektive Synthese und Folgechemie der p-Toluensulfonsäureester der Cellulose
[New functionalized polymers by regioselective synthesis and following reactions of cellulose p-toluenesulfonates]
June 1997 -
December 1999

TMWFK project
'Sekundärmetabolitbildung in Nahrungspflanzen' [Secondary metabolite formation in food plants]
FSU, Institute for Nutrition, Dept. 'Lebensmittel pflanzlicher Herkunft/ Pflanzenernährung', Prof. Dr. H. Bergmann

Qualitative und quantitative Bestimmung von Aminosäuren und biogenen Aminen in Pflanzenproben [Qualitative and quantitative estimation of amino acids and biogenous amines in plant samples]
  • Untersuchung von Streßmetaboliten in Pflanzenproben durch Entwicklung neuer Analysen- und Meßmethoden (HPLC-Meßtechnik, Shimadzu) [Investigation of stress metabolites in plant samples by development of new HPLC analysis and measuring methods]
  • Korrelation der Streßmetabolite mit der Schwermetallbelastung in den Pflanzenproben sowie im Boden [Formation of stress metabolites as indicators of plant stress and correlation of these biochemical stress response with the heavy metal plant and floor loading]
January 2000 -
January 2002

Industry project
with Novuspharma (Monza / Italy) 'Rational design of tubulin active compounds' [Rationales Design tubulinaktiver Verbindungen]
Institute for Molecular Biotechnology (IMB) Jena, Research group 'Molecular Cytology', Prof. Dr. E. Unger and Dept. 'Biocomputing', Dr. J. Sühnel

Tubulinaktive Verbindungen der Colchicinbindungstasche [Tubulin active compounds for the colchicine binding site]
  • Struktur-Wirkungsbeziehungen, CoMFA- und QSAR-Studien [Structure-activity relationships, CoMFA- and QSAR studies]
  • Ableitung von Strukturvorschlägen zur Synthese neuartiger Tubulinbinder [Suggestions and improvements for the synthesis of novel tubulin binders]
  • Docking- und Catalyst-Studien [Docking and catalyst studies]

February 2002 -
December 2007

BMBF project
'JCB - Jenaer Centrum für Bioinformatik'
Institute for Molecular Biotechnology (IMB) Jena, Dept. "Biocomputing", Dr. J. Sühnel

January 2008 -

Public relations
Fritz Lipmann Institute (FLI)

    • FLI homepage ...

Fields of Special Interests
cellulose and starch chemistry, renewable primary products, organic chemistry, chemistry of natural products
HPLC analysis, method development, estimation of amino acids and other stress metabolites in plant probes
drug design, structure-activity relationships, QSAR- and CoMFA studies, tubulin binders, anti-cancer drugs, Sybyl (Tripos)- and Catalyst (Accelrys) program
Web design, HTML, graphic design
bioinformatics, computational chemistry and biology, molecular modelling
education

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